Research

Peer Reviewed Articles from TW-ADNI

1. Zhu JD, Huang CW, Chang HI, Tsai SJ, Huang SH, Hsu SW, Lee CC, Chen HJ, Chang CC, Yang AC. Functional MRI and ApoE4 genotype for predicting cognitive decline in amyloid-positive individuals. Ther Adv Neurol Disord. 2022 Nov 19;15:17562864221138154. doi: 10.1177/17562864221138154. PMID: 36419870; PMCID: PMC9677312.

2. Weber CJ, Carrillo MC, Jagust W, Jack CR Jr, Shaw LM, Trojanowski JQ, Saykin AJ, Beckett LA, Sur C, Rao NP, Mendez PC, Black SE, Li K, Iwatsubo T, Chang CC, Sosa AL, Rowe CC, Perrin RJ, Morris JC, Healan AMB, Hall SE, Weiner MW. The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives. Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12226. doi: 10.1002/trc2.12226. PMID: 35005206; PMCID: PMC8719344.

3. Ni YC, Tseng FP, Pai MC, Hsiao IT, Lin KJ, Lin ZK, Lin WB, Chiu PY, Hung GU, Chang CC, Chang YT, Chuang KS; Alzheimer’s Disease Neuroimaging Initiative. Detection of Alzheimer's disease using ECD SPECT images by transfer learning from FDG PET. Ann Nucl Med. 2021 Aug;35(8):889-899. doi: 10.1007/s12149-021-01626-3. Epub 2021 Jun 2. PMID: 34076857.

4. Lee TH, Huang KL, Chang TY, Ho MY, Wey SP, Hsieh CJ, Yen TC, Lin KJ, Hsiao IT. Early-phase 18F-AV-45 PET imaging can detect crossed cerebellar diaschisis following carotid artery stenosis and cerebral hypoperfusion. Curr Neurovasc Res. 2017 Jun 21. doi: 10.2174/1567202614666170621102101. (PMID: 28637413)

5. Hsu JL, Hsu WC, Chang CC, Lin KJ, Hsiao IT, Fan YC, Bai CH. Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings. Sci Rep. 2017 May 11;7(1):1719. doi: 10.1038/s41598-017-01193-6. (PMID: 28496183 | Free PMC Article)

6. Kuo HC, Hsiao IT, Hsieh CJ, Huang CY, Huang KL, Wai YY, Chuang WL, Kung MP, Chu YC, Yen TC, Lin KJ, Huang CC. Dual-phase 18F-florbetapir positron emission tomography in patients with primary progressive aphasia, Alzheimer's disease, and healthy controls: A preliminary study. J Formos Med Assoc. 2017 Dec;116(12):964-972. (PMID: 28434708 | Free Article)

7. Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL. Biodistribution and radiation dosimetry for the tau tracer 18F-THK-5351 in healthy human subjects. J Nucl Med. 2017 Sep;58(9):1498-1503. (PMID: 28336780)

8. Li P, Hsiao IT, Liu CY, Chen CH, Huang SY, Yen TC, Wu KY, Lin KJ. Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study. EJNMMI Res. 2017 Dec;7(1):24. doi: 10.1186/s13550-017-0273-4. Epub 2017 Mar 21. (PMID: 28324341 | Free PMC Article)

9. Chang YT, Huang CW, Chen NC, Lin KJ, Huang SH, Chang WN, Hsu SW, Hsu CW, Chen HH, Chang CC.Hippocampal Amyloid Burden with Downstream Fusiform Gyrus Atrophy Correlate with Face Matching Task Scores in Early Stage Alzheimer's Disease.Front Aging Neurosci. 2016 Jun 17;8:145. (PMID: 27378917 | Free PMC Article)

10. Lin KJ, Hsiao IT, Hsu JL, Huang CC, Huang KL, Hsieh CJ, Wey SP, Yen TC. Imaging characteristic of dual-phase (18)F-florbetapir (AV-45/Amyvid) PET for the concomitant detection of perfusion deficits and beta-amyloid deposition in Alzheimer's disease and mild cognitive impairment. Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1304-14. (PMID:27003417)

11. Chang YT, Huang CW, Chen NC, Lin KJ, Huang SH, Chang YH, Hsu SW, Chang WN, Lui CC, Hsu CW, Chang CC. Prefrontal Lobe Brain Reserve Capacity with Resistance to Higher Global Amyloid Load and White Matter Hyperintensity Burden in Mild Stage Alzheimer's Disease. PLoS One. 2016 Feb 12;11(2):e0149056. (PMID: 26872386)

12. Wu KY, Liu CY, Chen CS, Chen CH, Hsiao IT, Hsieh CJ, Lee CP, Yen TC, Lin KJ. Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study. Eur J Nucl Med Mol Imaging. 2016 Jun;43(6):1067-76. (PMID: 26739329)

13. Weng YH, Chen CY, Lin KJ, Chen YL, Yeh TH, Hsiao IT, Chen IJ, Lu CS, Wang HL. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Exp Neurol. 2016 Jan;275 Pt 1:104-15. (PMID: 26363496)

14. Huang CY, Liu CH, Tsao E, Hsieh CJ, Weng YH, Hsiao IT, Yen TC, Lin KJ, Huang CC. Chronic manganism: A long-term follow-up study with a new dopamine terminal biomarker of 18F-FP-(+)-DTBZ (18F-AV-133) brain PET scan. J Neurol Sci. 2015;353(1-2):102-6. (PMID: 25936253)

15. Chang YT, Huang CW, Chang YH, Chen NC, Lin KJ, Yan TC, Chang WN, Chen SF, Lui CC, Lin PH, Chang CC. Amyloid burden in the hippocampus and default mode network: relationships with gray matter volume and cognitive performance in mild stage Alzheimer disease. Medicine (Baltimore). 2015 Apr;94(16):e763. (PMID: 25906109)

16. Chang CC, Hsiao IT, Huang SH, Lui CC, Yen TC, Chang WN, Huang CW, Hsieh CJ, Chang YY, Lin KJ. ¹⁸F-FP-(+)-DTBZ positron emission tomography detection of monoaminergic deficient network in patients with carbon monoxide related parkinsonism. Eur J Neurol. 2015 May;22(5):845-52, e59-60. (PMID: 25690304)

17. Yang ST, Hsiao IT, Hsieh CJ, Chiang YH, Yen TC, Chiu WT, Lin KJ, Hu CJ. Accumulation of amyloid in cognitive impairment after mild traumatic brain injury. J Neurol Sci. 2015 Feb 15;349(1-2):99-104. (PMID: 25586534)

18. Hsiao IT, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Lin KJ. Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography. JAMA Neurol. 2014 Jun;71(6):758-66. Erratum in: JAMA Neurol. 2014 Jun;71(6):803. (PMID: 24756323)

19. Hsiao IT, Weng YH, Lin WY, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lu CS, Lin KJ. Comparison of 99mTc-TRODAT-1 SPECT and 18 F-AV-133 PET imaging in healthy controls and Parkinson's disease patients. Nucl Med Biol. 2014 Apr;41(4):322-9. (PMID: 24503330)

20. Lin SC, Lin KJ, Hsiao IT, Hsieh CJ, Lin WY, Lu CS, Wey SP, Yen TC, Kung MP, Weng YH. In vivo detection of monoaminergic degeneration in early Parkinson disease by (18)F-9-fluoropropyl-(+)-dihydrotetrabenzazine PET. J Nucl Med. 2014 Jan;55(1):73-9. (PMID: 24287322)

21. Wu KY, Hsiao IT, Chen CS, Chen CH, Hsieh CJ, Wai YY, Chang CJ, Tseng HJ, Yen TC, Liu CY, Lin KJ. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging. 2014 Apr;41(4):714-22. (PMID: 24233127)

22. Lin KJ, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Hsiao IT. Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET. PLoS One. 2013 Sep 30;8(9):e75952. (PMID: 24098749)

23. Huang KL^, Lin KJ^, Ing-Tsung Hsiao IT, Kuo HC, Hsu WC, Chuang WL, Kung MP, Wey SP, Hsieh CJ, Wa YY, Yen TC*, Huang CC*. Regional Amyloid Deposition in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Evaluated by [18F]AV-45 Positron Emission Tomography in Chinese Population. PLOS ONE 2013. Accept 8 Feb 2013 [PONE-D-12-37760R1] (^Co-first author, *Co-corresponding author) (PMID: 23516589)

24. Hsiao IT^, Huang CC^, Hsieh CJ, Wey SP, Kung MP, Yen TC*, Lin KJ*. Perfusion-like Template and Standardized Normalization based Brain Image Analysis: using F-18 florbetapir (AV-45/Amyvid) PET. European Journal of Nuclear Medicine and Molecular Imaging (^Co-first author, *Co-corresponding author | Accepted on 2013-01-13 | Grant support: NSC-98-2314-B-182-034-MY2, 99-2314-B-182A-067-MY2, 100-2314-B-182-038, 100-2314-B-182A-092-MY3, 101-2314-B-182-061-MY2, and CMRPD1A0312) (PMID: 23412134)

25. Kung MP, Weng CC, Lin KJ, Hsiao IT, Yen TC, Wey SP. Amyloid plaque imaging from IMPY/SPECT to AV-45/PET. Chang Gung Med J. 2012 May-Jun;35(3):211-8. (PMID: 22735052)

26. Huang KL^, Lin KJ^, Ho MY, Chang YJ, Chang CH, Wey SP, Hsieh CJ, Yen TC, Hsiao IT*, Lee TH*. Amyloid deposition after cerebral hypoperfusion: Evidenced on [(18)F]AV-45 positron emission tomography. J Neurol Sci. 2012 Aug 15;319(1-2):124-9. (^Co-first author). (PMID: 22572706) (SCI, IF=2.353)

27. Hsiao IT^, Huang CC^, Hsieh CJ, Hsu WC, Wey SP, Yen TC, Kung MP*, Lin KJ*. Correlation of early-phase F-18 Florbetapir (AV-45/Amyvid) PET images to FDG images: Preliminary studies. Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):613-20. (PMID: 22270508) (SCI, IF=4.991)

28. Yao CH^, Lin KJ^, Weng CC, Hsiao IT, Ting YS, Yen TC, Jan TR, Daniel Skovronsky Kung MP, Wey SP*. GMP-compliant automated synthesis of [18F]AV-45 (Flobetapir F 18) for imaging beta-amyloid plaques in human brain. Appl Radiat Isot. 2010 Dec;68(12):2293-7. Epub 2010 Jul 7. (^Co-first author) (SCI；IF=1.094) (PMID: 20638295 | SCI, IF=0.999)

29. Lin KJ^, Hsu WC^, Hsiao IT, Wey SP, Jin LW, Daniel Skovronsky, Wai YY, Chang HP, Lo CW, Yao CH, Yen TC*, Kung MP*. Whole-Body Biodistribution and Brain PET Imaging with 18F-AV-45, a Novel Amyloid Imaging Agent-a Pilot Study. Nucl Med Biol. 2010 May;37(4):497-508. (^Co-first author) (SCI；IF=2.620) (PMID:20447562))

30. Wey SP, Weng CC, Lin KJ, Yao CH, Yen TC, Kung HF, Skovronsky D, Kung MP*. Validation of an 18F-labeled biphenylalkyne as a positron emission tomography imaging agent for β-amyloid plaques. Nucl Med Biol. 2009, 36(4): 411-417. (SCI；IF=2.620) (PMID:19423009 )

Abstract from TW-ADNI

1. Hsieh CJ, Lin KJ, Hunag CC, Yen TC, Hsiao IT. Correlation of symptom severity in dementia with dual time point 18F-Florbetapir (AV-45) imaging. 2015 SNMMI Annual Meeting, Baltimore, June 6-10, 2015.

2. Hsieh CJ, Lin KJ, Hunag CC, Yen TC, Hsiao IT. Comparison of perfusion-like information from 18F-Florbetapir (AV-45) and 18F-FDG PET images in patients with dementia. 2015 SNMMI Annual Meeting, Baltimore, June 6-10, 2015.

3. Tsao HH, Yen TC, Wey SP, Kung MP, Yang LY, Lin KJ. Pathologic studies of beta-amyloid deposition in APP/PS1 transgenic mice: [18F]AV45 in micro-autoradiography. The 11th International Conference on Alzheimer's & Parkinson's Diseases. Florence, Italy, March 6-10, 2013. (abstract A-459-0001-00714)

4. Chao KT, Yen TC, Tsao HH, Chang WC, Chen IJ, Yang LY, Hsiao IT, Wey SP, Kung MP, Lin KJ. Dynamic Amyloid PET Imaging in APP/PS1 Transgenic Mice Using [18F]AV-45. The 11th International Conference on Alzheimer's & Parkinson's Diseases. Florence, Italy, March 6-10, 2013. (abstract A-459-0001-00687)

5. Hsieh CJ, Fan L, Lin KJ, Hsiao IT, Huang CC, Wey SP, Kung MP, Skovronsky D, Yen TC. Precise F-18 florbetapir (AV-45) PET image spatial normalization using early-phase image template. 2011 SNM 58th Annual Meeting, San Antonio, Texas, USA. 4-8, Jun, 2011. Oral 549. (SNM travel award)

6. Hsieh CJ, Tsao HH, Lin KJ, Hsiao IT, Huang CC, Wey SP, Kung MP, Skovronsky D, Yen TC. Improved F-18 florbetapir (AV-45) PET imaging reading by brain cortex guide using dual time point scanning protocol. 2011 SNM 58th Annual Meeting, San Antonio, Texas, USA. 4-8, Jun, 2011. Poster 1256.

7. Hsieh CJ, Chao KT, Hsiao IT, Lin KJ, Huang CC, Wey SP, Kung MP, Skovronsky D, Yen TC. Correlation of early-phase F-18 Florbetapir (AV-45) PET images to FDG images. 2011 SNM 58th Annual Meeting, San Antonio, Texas, USA. 4-8, Jun, 2011. Poster 1292.

8. Huang CC, Lin KJ, Hsiao IT, Hsieh CJ, Hsieh YC, Wey SP, Kung MP, Skovronsky D, Yen TC. Comparison of F-18 Florbetapir (AV-45) and FDG PET scans between familial and sporadic alzheimer’s disease. 2011 the 10th international conference on Alzheimer’s & Parkinson’s diseases, Barcelona, Spain, March 9-13, 2011. Poster.

9. Huang CC, Lin KJ, Hsiao IT, Hsieh CJ, Kang HC, Hsieh YC, Wey SP, Kung MP, Skovronsky D, Yen TC. Regional amyloid plaque deposition in MCI and Alzheimer’s disease evaluated by F-18 Florbetapir (AV-45) PET scans. 2011 the 10th international conference on Alzheimer’s & Parkinson’s diseases, Barcelona, Spain, March 9-13, 2011. Poster.

10. Weng CC, Lin KJ, Shen James CK, Tsai KJ, Yen TC, Daniel M. Skovronsky, Wey SP, Kung MP, Plaque detection with a novel PET amyloid imaging agent, [18F]AV-45 in a transgenic mouse model. 2010 World Molecular Imaging Congress, Kyoto, Japan. September 8-11, 2010.Oral.

11. Lin KJ, Kung MP, Hsu WC, Hsiao IT , Wey SP, Daniel M. Skovronsky, Wai YY, Chan HP, Lo CW, Yao CH, Yen TC. Human Radiation Dosimetry and Whole-Body Biodistribution for a Novel Amyloid Imaging Agent –18F-AV-45. 2009 World Molecular Imaging Congress (WMIC), Montreal, Canada, September 23-26, 2009. Poster